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Schematic representation of the nucleosome, the smallest subunit of the chromatin. The DNA (grey) is wrapped around the nucleosomal core proteins, the histones H2A (yellow), H2B (red), H3 (blue), and H4 (green).

Histones are proteins that compact the DNA in chromosomes.[1] They are highly alkaline proteins present in the nuclei of eukaryotic cells that package and order the DNA into structural units called nucleosomes.


  1. Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walters, Peter (2008). Molecular Biology of the Cell (5th ed.). New York and London: Garland Science. p. 63. ISBN 0-8153-4105-9.