Genetic Entropy is the theory that genetic mutations are accumulating to an eventual extinction of all species. The theory was originally proposed by Joseph Muller in 1932 and named Muller's Ratchet, he imagined it as a means by which selection forced asexual populations to evolve sexual reproduction. The geneticist John C. Sanford has further expanded on the theory in a more realistic framework from the Biblical worldview, and published the work in a book titled Genetic Entropy & the Mystery of the Genome.
One of the problems of the secular version of the theory is their belief that natural selection weeds out the deleterious mutations and solves the problem. But, natural selection can only select individuals and not mutations and since selection coefficients change over time there is no observable instance of favorable individuals either.
The rate of deleterious mutations has been determined to be an incredible one per gamete. 
And the rate of known genetic disorders arising is solid confirmation of this fact.
- Main Article: Human longevity
Given the fact that the bible was written without any previous knowledge of genetics, it is highly unlikely that the ages and dates of the patriarchs given in the Bible would follow a biological decay curve predicted by genetic entropy by chance. Given these facts it is only reasonable that genetic entropy is not only a solid confirmation of genomic decline in which falsifies the central tenet of evolution, but makes clear predictions about the declining age of humanity over time as documented in the bible.
- Muller's Ratchet Wikipedia
- Sanford, John C. Genetic Entropy & the Mystery of the Genome (2005)
- Genome-wide analysis of a long-term evolution experiment with Drosophila Nature 467, 587–590 (30 September 2010)
- Crow and Simmons 1983; Bell 1988; Kondrashov 1988; Charlesworth et al. 1990; Houle et al. 1992
- Mastropaolo, Joseph Evolution is Lethal Antiscience: Creation Research Society Quarterly Volume 38, December 2001
- Patriarchal Life Span Exponential Decay by Base e: Charles A. Glatt Jr.