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Gene conversion

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Diagram comparing the gene conversion with crossover: a) Gene Conversion b) Crossover

Gene conversion occurs when one allele of a gene is lost and is then, replaced by an alternative allele.[1] Gene conversion is a process that occurs without having been a reciprocal recombination event. The conversion of the gene can be classified into allelic where one allele of the same gene replaces another allele, or ectopic, when a paralogous DNA sequence converts another. Genetic studies have shown that, typically, only small sections of DNA undergo gene conversion, and in many cases, only a portion of a gene is altered.[2]


  1. Watson, Jamed D.; Baker, Tania A.; Bell, Stephen P.; Gann, Alexandrer; Levine, Michael. Losick, Richard (2004). Molecular Biology of the Gene (5th ed.). San Francisco, CA: Pearson, Benjamin Cummings/CSHL Press. p. 284. ISBN 0-8053-4642-2. 
  2. Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walters, Peter (2008). Molecular Biology of the Cell (5th ed.). New York and London: Garland Science. p. 314. ISBN 0-8153-4105-9.