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[[Image:Apoptosisprocess.jpg|250px|thumb|right|Apoptosis from irreparable mutation]] | [[Image:Apoptosisprocess.jpg|250px|thumb|right|Apoptosis from irreparable mutation]] | ||
Cell signals control process of apoptosis. | Cell signals control process of apoptosis. These cell signals are either extracellular or intracellular. | ||
Hormones, growth factors, nitric oxicers, and cytokines are extracellular signals, | Hormones, growth factors, nitric oxicers, and cytokines are extracellular signals, in that they cross plasma membranes. Intercellular signals are cell stress, cell suicide, heat, radiation, nutrient deprivation, and viral infection. [http://en.wikipedia.org/wiki/Apoptosis] | ||
===Pathways=== | ===Pathways=== | ||
Apoptosis occurs within extrinsic pathway and intrinsic | Apoptosis occurs within extrinsic pathway and intrinsic pathways. Extrinsic pathway occurs by the simulation of a death receptor which is located on the plasma membrane. (Ligands are signal molecules that simulate death receptors.) Intrinsic pathway occurs by releasing of signals within mitochondria cells. (Cellular stress triggers intrinsic pathway. Cell stress is caused by DNA damage and heat shock.) [http://www.scq.ubc.ca/?p=350] | ||
Studying and understand pathways of apoptosis will help to prevent and treat diseases. | Studying and understand pathways of apoptosis will help to prevent and treat diseases. | ||
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=====HIV===== | =====HIV===== | ||
HIV, Human Immunodeficiency Virus, has gene that cannot kill infected cells by apoptosis pathway. It happens when host’s immune system becomes weak. The host’s immune system becomes weak, because of wrong pathway of apoptosis programs to kill immune cells. In other words, number of immune cells is decreased by wrong pathway of apoptosis. [http://www.scq.ubc.ca/?p=350] | HIV, Human Immunodeficiency Virus, has gene that cannot kill infected cells by apoptosis pathway. It happens when host’s immune system becomes weak. The host’s immune system becomes weak, because of wrong pathway of apoptosis programs to kill immune cells. In other words, number of immune cells is decreased by wrong pathway of apoptosis. [http://www.scq.ubc.ca/?p=350] | ||
==Function of Apoptosis== | ==Function of Apoptosis== |
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