Hemostasis: Difference between revisions

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Hemostasis is composed of four major processes in a set order. '''Vascular constriction''' is the first step of hemostasis. It stops the blood flow to the area that is injured. When a person gets injured, Vascular constriction occurs to prevent excessive bleeding. After vascular constriction, thrombin activates platelets and they aggregate at the site of the injury, and loose platelet fibrogen. After thrombin activates platelets, the clot forms and entraps the plug. '''White thrombus''' is present when the plug contains only platelets; a '''red thrombus''' is present when red blood cells are present. Finally, the process proceed the last step, [[tissue repair]]. the clot is dissolved in normal blood flow. The clot is dissolved through the action of plasmin. <ref>[http://themedicalbiochemistrypage.org/blood-coagulation.html The Medical Biochemistry] Michael W. King, Ph.D, IU School of Medicine, February 24, 2011.</ref>
Hemostasis is composed of four major processes in a set order. '''Vascular constriction''' is the first step of hemostasis. It stops the blood flow to the area that is injured. When a person gets injured, Vascular constriction occurs to prevent excessive bleeding. After vascular constriction, thrombin activates platelets and they aggregate at the site of the injury, and loose platelet fibrogen. After thrombin activates platelets, the clot forms and entraps the plug. '''White thrombus''' is present when the plug contains only platelets; a '''red thrombus''' is present when red blood cells are present. Finally, the process proceed the last step, [[tissue repair]]. the clot is dissolved in normal blood flow. The clot is dissolved through the action of plasmin. <ref>[http://themedicalbiochemistrypage.org/blood-coagulation.html The Medical Biochemistry] Michael W. King, Ph.D, IU School of Medicine, February 24, 2011.</ref>


== Blood Clotting ==
== Blood Clots ==
 
'''Blood clotting''' is a disease that is caused by a thickened mass in the blood. Blood clotting stops blood flowing, like coagulation. Blood clotting happens to prevent from shocking or possibility of death. However,  blood clotting is way faster than the process of coagulation and it has red blood cells.<ref name=Blood Clotting System>[http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html Blood Clotting] John W. Kimball, Kimball's Biology, January 11th, 2011.</ref>


'''Blood clotting''' is a disease that is caused by a thickened mass in the blood. Blood clotting stops blood flowing, like coagulation. Blood clotting happens to prevent from shocking or possibility of death. However,  blood clotting is way faster than the process of coagulation and it has red blood cells.


* Process
* Process
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* Controlling Clotting
* Controlling Clotting


Blood clotting system is controlled by antithrombin III, heparin, protein C, vitamin K, and warfarin (Coumadin). Antithrombin III is a plasma protein (a serpin) prevents the formation of thrombin by binding to prothrombin. Heparin is a mixture of polysaccharides that bind to antithrombin III. Protein C is a protein that sits at the center of the control mechanism system. It excess thrombin binds to cell-surface receptors, called thrombomodulin. Vitamin K is a cofactor needed for the synthesis of protein S. Lastly, warfarin is another name of blood thinner because it is an effective vitamin K antagonist.<ref name=Blood Clotting System>[http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html Blood Clotting] John W. Kimball, Kimball's Biology, January 11th, 2011.</ref>
Blood clotting system is controlled by antithrombin III, heparin, protein C, vitamin K, and warfarin (Coumadin). Antithrombin III is a plasma protein (a serpin) prevents the formation of thrombin by binding to prothrombin. Heparin is a mixture of polysaccharides that bind to antithrombin III. Protein C is a protein that sits at the center of the control mechanism system. It excess thrombin binds to cell-surface receptors, called thrombomodulin. Vitamin K is a cofactor needed for the synthesis of protein S. Lastly, warfarin is another name of blood thinner because it is an effective vitamin K antagonist.<ref name=Blood Clotting System></ref>
 


== References ==
== References ==
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