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Hemostasis: Difference between revisions
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→Blood Clotting
Jaehoon Jang (talk | contribs) |
Jaehoon Jang (talk | contribs) |
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* Process | * Process | ||
A blood clotting consists of a plug of platelets enmeshed in a network of insoluble fibrin molecules. Blood clotting requires calcium ions (Ca<sup>2+</sup>) so the blood do not clot in the bag. This system also requires about a dozen other protein clotting factors. <ref name=Blood Clotting System>[http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html Blood Clotting] | A blood clotting consists of a plug of platelets enmeshed in a network of insoluble fibrin molecules. Blood clotting requires calcium ions (Ca<sup>2+</sup>) so the blood do not clot in the bag. This system also requires about a dozen other protein clotting factors. <ref name=Blood Clotting System>[http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html Blood Clotting] John W. Kimball, Kimball's Biology, January 11th, 2011.</ref> | ||
* Controlling Clotting | * Controlling Clotting | ||
Blood clotting system is controlled by antithrombin III, heparin, | Blood clotting system is controlled by antithrombin III, heparin, protein C, vitamin K, and warfarin (Coumadin). Antithrombin III is a plasma protein (a serpin) prevents the formation of thrombin by binding to prothrombin. Heparin is a mixture of polysaccharides that bind to antithrombin III. Protein C is a protein that sits at the center of the control mechanism system. It excess thrombin binds to cell-surface receptors, called thrombomodulin. Vitamin K is a cofactor needed for the synthesis of protein S. Lastly, warfarin is another name of blood thinner because it is an effective vitamin K antagonist.<ref name=Blood Clotting System>[http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html Blood Clotting] John W. Kimball, Kimball's Biology, January 11th, 2011.</ref> | ||
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== References == | == References == | ||
