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Hemoglobin: Difference between revisions
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Hemoglobin synthesis requires the coordination of heme and globin. Heme is the prosthetic group of hemoglobin, myoglobin, and the cytochromes. Globin is the protein that protects the heme molecule. In the mitochondria and the cytosol of immature red blood cells, the heme part is synthesized in a series of steps. On the other hand, the globin protein parts are synthesized by ribosomes in the cytosol. From the proerythroblast to the reticulocyte in the bone marrow, the production of hemoglobin continues in the cell. Then the nucleus disappears in mammalian red blood cells in only humans not in other species. Although the nucleus is lost in red blood cells, residual ribosomal RNA keeps synthesizing hemoglobin until reticulocyte loses its RNA as soon as it enters the vasculature. | Hemoglobin synthesis requires the coordination of heme and globin. Heme is the prosthetic group of hemoglobin, myoglobin, and the cytochromes. Globin is the protein that protects the heme molecule. In the mitochondria and the cytosol of immature red blood cells, the heme part is synthesized in a series of steps. On the other hand, the globin protein parts are synthesized by ribosomes in the cytosol. From the proerythroblast to the reticulocyte in the bone marrow, the production of hemoglobin continues in the cell. Then the nucleus disappears in mammalian red blood cells in only humans not in other species. Although the nucleus is lost in red blood cells, residual ribosomal RNA keeps synthesizing hemoglobin until reticulocyte loses its RNA as soon as it enters the vasculature. | ||
== Types == | == Types == | ||
== Uses == | == Uses == | ||
