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The paper released titled, ''Complete genetic linkage can subvert natural selection'' states that: | The paper released titled, ''Complete genetic linkage can subvert natural selection'' states that: | ||
{{cquote| The key fact is that natural selection, although eminently robust, is a short-sighted process that favors traits with immediate fitness benefits. The fitness cost of mutator hitchhiking is generally not anticipated because of the slow accumulation of deleterious load. When a mutator hitchhikes with a new beneficial mutation, a simple model shows that the increased deleterious load due to the mutator is in fact suppressed during the spread of the beneficial mutation. Indeed, the full fitness cost of the mutator is only realized well after the beneficial mutation has stopped spreading. A mutator may therefore enjoy the immediate benefit of producing a new beneficial mutation without anticipating the eventual increase in deleterious load. Because of this delay in the accumulation of deleterious load, natural selection can drive mutation rate up to the point of no return. | {{cquote| The key fact is that natural selection, although eminently robust, is a short-sighted process that favors traits with immediate fitness benefits. The fitness cost of mutator hitchhiking is generally not anticipated because of the slow accumulation of deleterious load. When a mutator hitchhikes with a new beneficial mutation, a simple model shows that the increased deleterious load due to the mutator is in fact suppressed during the spread of the beneficial mutation. Indeed, the full fitness cost of the mutator is only realized well after the beneficial mutation has stopped spreading. A mutator may therefore enjoy the immediate benefit of producing a new beneficial mutation without anticipating the eventual increase in deleterious load. Because of this delay in the accumulation of deleterious load, natural selection can drive mutation rate up to the point of no return. | ||
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There is almost certainly no physiological barrier to such an effect in most organisms: the genomic mutation rate in organisms from viruses to eukaryotes is a quantitative trait affected by many mutations whose effects can readily cumulate to intolerable levels of error. In what follows, we show that there need not be a selective barrier to this process either: because the full fitness effect of increased deleterious mutation takes some time to accumulate after a higher mutation rate has evolved, it is theoretically possible for a population to evolve a critically high mutation rate and subsequently go extinct. [http://www.pnas.org/cgi/content/full/104/15/6266] }} | There is almost certainly no physiological barrier to such an effect in most organisms: the genomic mutation rate in organisms from viruses to eukaryotes is a quantitative trait affected by many mutations whose effects can readily cumulate to intolerable levels of error. In what follows, we show that there need not be a selective barrier to this process either: because the full fitness effect of increased deleterious mutation takes some time to accumulate after a higher mutation rate has evolved, it is theoretically possible for a population to evolve a critically high mutation rate and subsequently go extinct. [http://www.pnas.org/cgi/content/full/104/15/6266] }} | ||
