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Senescence: Difference between revisions
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Cellular senescence is the reproduction limits of normal cells. Most normal cells can divide up to 40 or 60 times before they are unable to divide anymore. This is referred to as he Hayflick Limit, after Dr. Leonard Hayflick who discovered cellular senescence. Some cells do not have this limit, though. These cells are cancer cells, and they can divide infinitely. [http://websites.afar.org/site/PageServer?pagename=IA_b_sene_01_what] | Cellular senescence is the reproduction limits of normal cells. Most normal cells can divide up to 40 or 60 times before they are unable to divide anymore. This is referred to as he Hayflick Limit, after Dr. Leonard Hayflick who discovered cellular senescence. Some cells do not have this limit, though. These cells are cancer cells, and they can divide infinitely. [http://websites.afar.org/site/PageServer?pagename=IA_b_sene_01_what] | ||
Senescence is | Senescence is thought to be due to the degradation of [[telomeres]]. Telomeres are caps at the end of chromosomes that prevent chromosomes from fusing together. After each division of the cell, the length of the telomere shortens. When the telomere is finally gone, the cell cannot divide anymore and dies. Cancer cells can avoid this eventual death by introducing telomerase into its cells. Telomerase is a reverse-transcriptase enzyme that makes the telomeres longer after each division, thus preventing them from disappearing. [http://www.senescence.info/telomeres.html] | ||
== Apoptosis == | == Apoptosis == | ||
