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Immune system

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Image:White blood cell TEM.jpg|[[Transmission electron microscope]] image of a thin section cut through a human leukocyte (white blood cell) of the type Eosinophil. Eosinophils contain eosinophil granules that are large (0.1-1.0micron) spherical, membrane-bound structures, containing a dense and lamellated crystalloid core.
Image:White blood cell TEM.jpg|[[Transmission electron microscope]] image of a thin section cut through a human leukocyte (white blood cell) of the type Eosinophil. Eosinophils contain eosinophil granules that are large (0.1-1.0micron) spherical, membrane-bound structures, containing a dense and lamellated crystalloid core.
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== References ==
== References ==

Revision as of 17:33, 1 July 2010

Organs of the Immune System.

The immune system is a bodywide network of white blood cells (leukocytes), tissues, and organs that was designed to defend the body against "foreign" invasions. The proper targets of the immune system are infectious organisms--bacteria such as streptococci; fungi; parasites, including the worm-like microbes that cause malaria; and viruses such as the SARS virus.[1]

The immune system includes two main responses: the humoral immune response and the cellular immune response. The humoral immune response produces antibodies and the cellular immune response kills the infected cells. [2]

Contents

Humoral response

Immune cells communicate with each other through cell-to-cell contact. Cells touch using surface receptors-this can cause a cell to carry out a function like seeking out invading bacteria. Another way cells communicate is by using chemicals (like hormones and cytokines) that are produced by different types of cells. Chemicals travel throughout the body via blood and tissues. They bind to surface receptors on certain cells to deliver a signal.

The Humoral Immune Response is the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell), as opposed to cell-mediated immunity which involves T lymphocytes (T cell). Secreted antibodies bind to antigens (substance such as a toxin or enzyme that stimulates an immune response). Antigens may be found on the surfaces of invading microbes (such as viruses or bacteria). Binding by antibodies flags the antigen for destruction.[3]

B Cells

B cells and T cells are the most abundant lymphocytes. B cells are the basis for the humoral immune response. B cells work mainly by secreting soluble substances known as antibodies. It’s developed into an antibody-secreting plasma cell; a helper T cell with the same specificity must also bind to the antigen. When the B cells received a chemical signals form the T cells, it divided and differentiated the B cells and then it leads to the formation of plasma cells. As the plasma cells develops the number of ribosomes and the amount of endoplasmic reticulum in the cytoplasm will also increased. The plasma cells arising because of the antibodies that produced by the B cells which specific for the antigen that bound to the parent B cells. The antibody’s specific was maintained by the B cell’s proliferate.(Purves, p374)

Antibodies

Immunoglobulin G is a type of antibody that circulates in the blood and recognizes foreign particles that might be harmful.

Antibodies are "Y" shaped proteins, which aclled immunoglobulins. They are produced in the blood or tissues in response to a specific antigen, such as a bacterium or a toxin. Antibodies destroy or weaken bacteria and neutralize organic poisons, thus forming the basis of immunity.

Antibody consisting four polypeptide chains, two of these is called light chains and heavy chains. They were holding together by the disulfide bonds. Each of the polypeptide consists of a variable region and constant region.

Variable Region is a region in an immunoglobin molecule that shows many sequence differences between antibodies of different specificities; the part of the antibody that binds to the antigen. Constant Region is the portion of the carboxyl terminal of an immunoglobulin's heavy and light chains having an amino acid sequence that does not vary within a given class or subclass of immunoglobulin. The constant region determine the class of the antibody. (Purves, p375)

There are five classes of antibody: IgG, IgM, IgD, IgA, and IgE. These monoclonal antibodies are produced by hybridomas. IgG is the most abundant immunoglobulin class. It is soluble and it make up nearly 80 percent of the total immunoglobulin content of the bloodstream. (Purves, p375) IgG could move through placenta into the fetus' blood. IgA could move through the alimentary canal and is the main reason for the mucus membranes could prevent infecting again by the same bacteria.

Antigens are the things bound by the antibodies. Antigens are the macromolecules that elicit an immune response in the body, they are proteins, and polysaccharides. The antigens are a substance that when introduced into the body stimulates the production of an antibody. Antigens include toxins, bacteria, foreign blood cells, and the cells of transplanted organs. They are killing by the antibodies when they were recognized by the T cells, and the T cells will let the B cell know and the B cells will eventually produced the antigens to kill the antigens.

Immunity

Immunity or immunological memory is an ability of immunity system to remember exposures to foreign particles, sometimes for decades. This ability is due to a type of B cell called a Memory cell.(Purves, p372)

Immunization or vaccinations are designed to take advance of immunological memory. By exposing the immune system to either protein fragment or whole pathogens that have been modified so they don't cause disease, a primary immune response is initiate during which memory cells are made.(Purves, p372)

There are two types of immunity. Innate immunity, adaptive immunity or passive immunity. Innate immunity is the immunity that born with our body. It also included the external barrier, like our skins, and those mucous membranes, like our nose, throat, and stomach. When the first line of defence was broken, as when you cut your finger, our innate immunity will produce some special immunity cells to attack the germs and at the same time the immune system are trying to heal the wound as soon as possible.

The adaptive immunity will keep developing until we die. This kind of immunity involves lymphocytes. The vaccination is one way of defending against the diseases like small poxes, chicken poxes, etc. When we accept this kind of vaccination, we will never infect the same disease again. There are two types of adaptive immunity: Natural immunity and Artificial immunity. Natural immunity has two branches, maternal, which is passive; infection, which is active. Artificial immunity also has two branches, antibody transfer and immunization, these two are also passive and active. [1]

Passive immunity is the immunity acquired by the transfer of antibodies from another individual, as through injection or placental transfer to a fetus. This transfer may protect your early childhood not affect by the germs. And when you getting older, it's hard for you to catch a cold, because your body could recognise the cold germs, so the immunity will try their best to prevent you from the cold germs. That's why adults are much stronger then little kids. [2]

Cellular response

T Cells

This T cell (blue), one of the immune system’s principle means of defense, identifies the molecular signature of a dendritic cell (green) at a junction between the two called the immunological synapse. If the immunological synapse signals the presence of a foe, the T cell will attack.

In addition to having a role in the humor immune response, T cells are the effectors in the cellular immune response, which is directed at any factor such as a virus or mutation that has changed a normal cells into an abnormal cells. There are two types of T Cells exist. One called helper T cells and the other called cytotoxic T cells.

T cell receptors are not immunoglobulins, but glycoproteins with molecular weights about half that of an IgG. They consists two polypeptide chains, and each on them encoded by a separate gene. Therefore this two chains are different in their amino acid sequence, especially in their variable regions.(Purves, p378)

The most important cells among the T cells are the helper T cells. They are needed to activate many immune cells, including B cells and other T cells. [3]

There is one major difference between the T cell receptors and the antibodies. While the antibodies bind to an intact antigen the T cells bind to a piece of the antigen displayed on the surface of an antigen-presenting cell. (Purves, p378)

Antigen-Presenting and T Cell Types

Presenting Cell Type Antigen Presented MHC Class T Cell Type T Cell Surface Protein
Any Cell Intracellular protein fragment Class I Cytotoxic T cell CD8
Macrophages and B cells Fragments from extracellular proteins Class II Helper T CD4

Cytotoxic T Cells

Cytotoxic T Cells recognize virus-infected cells and kill them by inducing lysis. (Purves, p378) Cytotoxic T cells will prevent those viruses infect your cell. They will kill the infected cell and keep your body healthy. And they are also responsible for the rejection of tissue and organ grafts.[4]

Cytotoxic T cells could recognizes and binds to the MHC I by its surface protein which called CD8. And it also releases perforin, granulysin, and a serine protease which called geanzyme. The perforin and granulysin are cytotoxins, they form pores in the target cell's plasma membrane causing ions and water to flow into the target cell that make the cell expand and eventually undergo lysis. [5]

Helper T Cells

Helper T Cells assist both the cellular and humoral immune responses. It must binds to an antigen presented on a B cell before it become activated.(Purves, p378) Helper T cells have a surface protein called CD4 that recognizes MHC II.

There are three types of helper T cells: Th1, Th2, and Th17. Basically Th1 are the cells which could control the intracellular pathogen like viruses and bacteria. Th2 are the cells that help the B cells and are the basic of antibody-mediated immunity. And they are essential in the control of extracellular pathogens. Th17n are the prevent the inbreak of the invaders at the surface.

Type Cytokine Stimulus Master Transcription Factor Effector Cytokine(s) Effector Functions Pathological Effects
TH1 IL-12 T-bet IFN-γ Intracellular pathogens Autoimmunity; cell-mediated allergies
Th2 IL-4 GATA-3 IL-4 Extracellular pathogens Asthma and IgE-mediated allergies
Th17 TGF-β plus IL-6 Inhibited by retinoic acid RORγ IL-17 & IL-22 Extracellular bacteria; mediates inflammation Autoimmune diseases
Treg TGF-β minus IL-6 Stimulated by retinoic acid Foxp3 TGF-β Immunosuppression; anti-inflammatory None?
[6]

Self Recognition

The Major Histocompatibility Complex (MHC) are the major proteins in establishing self-tolerance, without the possibility of an animal destroyed by its own immune system. MHC proteins are responsible for transplant rejection. The proteins produced by the MHC are specific to each individual so they act as antigens if transplanted into another individual.

When an organ transplanted from one to the other is recognizes as nonself, it will be rejected by the immune system, but if it comes from a genetically identical person, then it is not rejected. Those rejection problem could be solved by using drugs such as cyclosporin which suppress the immune system. (Purves, p381)

Usually, the MHC is divided into the class I, II and II regions, each containing groups of genes with related functions.

Antibody Diversity

Disease

When your immune system malfunctions, it can unleash a torrent of disorders and diseases.[7] If a person is born with a severely defective immune system, death from infection by a virus, bacterium, fungus or parasite will occur. In severe combined immunodeficiency, lack of an enzyme means that toxic waste builds up inside immune system cells, killing them and thus devastating the immune system.[8]

Allergies

One of the most familiar immune disorders is allergy. Allergies such as hay fever and hives are related to the antibody known as IgE. The first time an allergy-prone person is exposed to an allergen--for instance, grass pollen--the individual's B cells make large amounts of grass pollen IgE antibody. These IgE molecules attach to granule-containing cells known as mast cells, which are plentiful in the lungs, skin, tongue, and linings of the nose and gastrointestinal tract. The next time that person encounters grass pollen, the IgE-primed mast cell releases powerful chemicals that cause the wheezing, sneezing, and other symptoms of allergy.[9]

Autoimmunity

Most other immune disorders result from either an excessive immune response or an 'autoimmune attack '.[10] This happens when immune system's recognition apparatus breaks down, and the body begins to manufacture antibodies and T cells directed against the body's own cells and organs. Such cells and autoantibodies, as they are known, contribute to many diseases. For instance, T cells that attack pancreas cells contribute to diabetes, while an autoantibody known as rheumatoid factor is common in persons with rheumatoid arthritis.[11]

Asthma, familial Mediterranean fever and Crohn's disease (inflammatory bowel disease) all result from an over-reaction of the immune system, while autoimmune polyglandular syndrome and some facets of diabetes are due to the immune system attacking 'self' cells and molecules. A key part of the immune system's role is to differentiate between invaders and the body's own cells - when it fails to make this distinction, a reaction against 'self' cells and molecules causes autoimmune disease.[12]

Immunodeficiency

Main Article AIDS

When the immune system is lacking one or more of its components, the result is an immunodeficiency disorder. These disorders can be inherited, acquired through infection, or produced as an inadvertent side effect of drugs such as those used to treat cancer or transplant patients.

AIDS is an immunodeficiency disorder caused by a virus that destroys helper T cells. The virus copies itself incessantly and invades helper T cells and macrophages, the very cells needed to organize an immune defense. The AIDS virus splices its DNA into the DNA of the cell it infects; the cell is thereafter directed to churn out new viruses.[13]

A lack of immune system cells is also the basis for DiGeorge syndrome: improper development of the thymus gland means that T cell production is diminished.[14]

Gallery

References

  1. Understanding Cancer Series: The Immune System by the the National Cancer Institute
  2. Purves, et. al. Life: The Science of Biology. 2004. Sinauer Associates, Inc. W.H. Freeman and Company, p370.
  3. Pier GB, Lyczak JB, Wetzler LM (2004). Immunology, Infection, and Immunity. ASM Press. ISBN 1-55581-246-5.
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